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The purpose of this paper is to quantify the human health impacts of soy-biodiesel production with the aim to discuss about its environmental sustainability.

The integrated use of two current approaches, risk assessment (RA) and life cycle assessment (LCA), has allowed improvement of the potentialities of both in obtaining a more complete analysis. The implementation of a life cycle indicator for the assessment of the impacts on the human health, integrating the features of both approaches, is the main focus of this paper.

It has been found that, although the biodiesel is a green fuel, it has some criticalities in its life cycle, which cannot be disregarded. In fact, even if biodiesel is essentially a clean fuel there are some phases, prior to the industrial phase, that can cause negative effects on human health and ecosystems.

Results suggest some measures which can be adopted to substantially reduce human health impacts. Further alternative could be analysed in future to gain more insight about the use of biodiesel fuels.

The estimation of the impacts of a process producing biodiesel has been made by using a novel approach. The novelty is associated with the calculation of the impacts on human health by using the transfer factors applied in RA. The use of such factors, properly modified in order to estimate the impacts on a wider scale than a site-dimension, allows defining a holistic approach, as LCA and RA are used as complete units but at the same time can be related to each other.